Recombinant DNA and induced tumours

Recombinant DNA.

Recombinant Dna Technology and Biotechnology

Introduction Application on industrial production of biomolecules Human therapeutics from recombinant DNA technology Success story of Insulin Host used for therapeutic production Safety of the recombinant biomolecules Human monoclonal antibody Application in Agriculture Development of stress tolerant plant Development of plant having improved yield Transgenic plant as a source of bio pharmaceut...

Carcinogen-induced impairment of enzymes for replicative fidelity of DNA and the initiation of tumours.

Not all carcinogens are mutagens, and many mutagens are not carcinogens. Among related chemicals, small changes of structure can markedly influence carcinogenic potency. Many tumours are genetically unstable, but some, especially 'benign' types, rarely exhibit 'progression' or show other evidence of genetic instability. Cells of particular tumour types exhibit identifiable particular 'sets' of ...

The recombinant-DNA debate.

REPORTS Recombinant DNA: Examples ofPresent-Day Research:J.Abelson. Charon Phages: Safer Derivatives ofBacteriophage Lambda forDNA Cloning: F. R. Blattner et al. . Recombinational Switch for Gene Expression: J. Zieg et al. Gene Cloning and Containment Properties of Plasmid Col El and Its Derivatives: K. A. Armstrong, V. Hershfield, D. R. Helinski. EK2 Derivatives ofBacteriophage Lambda Useful i...

DNA ploidy in bronchopulmonary carcinoid tumours.

Fifty three bronchopulmonary carcinoid tumours were studied to assess the significance of DNA ploidy, determined by flow cytometry of paraffin embedded tissue. Twenty eight were typical carcinoid tumours and 25 well differentiated neuroendocrine carcinomas. Twenty seven were DNA diploid and 26 DNA aneuploid. DNA aneuploidy was significantly associated with histological features of increased mal...